Using a Wacom pen tablet inside VirtualBox 6

I have the tablet wacom intuos pen & touch small CTH-480, which I wanted to use for photo editing in Adobe Lightroom. Since I work under Linux Mint 20, I have a virtual machine running Windows 10 and Lightroom Classic 10. Unfortunately, I got the pen to work as a mouse only by disabling it as an input device, which prevents the buttons from being configurable in the Wacom Desktop Center app.

If I turn the tablet in the USB settings on, the Wacom Desktop Center properly detects the tablet, but movements of the pen are not translated into mouse pointer movements.